Wellcome-CTC Mouse Strain SNP Genotype Set
Heterogeneous Stock QTL Project
QTL Mapping with Outbred MF1 Mice
Complex Trait Consortium Meeting, Oxford 1-3 July 2003
Estimation of the probability of ENU0induced coding mutations
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QTL Fine-mapping in Outbred MF1 Mice
Genetic Dissection of a behavioral qunatitative trait locus shows that Rgs2 modulates anxiety in mice
Nature Genetics 36, 1197 - 1202 (2004)
Yalcin B, Willis-Owen SA, Fullerton J, Meesaq A, Deacon RM, Rawlins JN, Copley RR, Morris AP, Flint J, Mott R.
Here we present a strategy to determine the genetic basis of variance in complex phenotypes that arise from natural, as opposed to induced, genetic variation in mice. We show that a commercially available strain of outbred mice, MF1, can be treated as an ultrafine mosaic of standard inbred strains and accordingly used to dissect a known quantitative trait locus influencing anxiety. We also show that this locus can be subdivided into three regions, one of which contains Rgs2, which encodes a regulator of G protein signaling. We then use quantitative complementation to show that Rgs2 is a quantitative trait gene. This combined genetic and functional approach should be applicable to the analysis of any quantitative trait.
Link to Nature Genetics
